Friday, January 27, 2012

CAM Under Attack!

In the News At some point, nearly 4 of every 10 American adults use complementary and alternative medicine, or CAM; often to treat various types of acute or chronic pain. Personal, out-of-pocket expenditures for CAM each year add up to roughly $43-billion, even though many CAM therapies have not been scientifically established as beneficial. So, it is somewhat surprising that a recent news report challenges expenditures by the U.S. government to evaluate the safety and effectiveness of those therapies.

Under the headline, “Funding of Alternative Treatments Questioned,” in a recent edition of the Los Angeles Times [January 23, 2012], writer Trine Tsouderos explains, “Some see tax dollar waste in spending by the National Center for Complementary and Alternative Medicine. The NCCAM director, though, sees a need for scientific attention.” Along with that, several examples of allegedly frivolous funding are provided in the article:

Thursday, January 19, 2012

More About Yoga for Pain, and Its Harms

YogaYoga, of which there are numerous types, is an increasingly popular mind-body intervention for select pain conditions. The modality consists of specific physical postures, breathing techniques, and mental concentration or meditation exercises. A number of clinical studies have examined the benefits of yoga as an adjunct for chronic pain management, but until now there has not been a meta-analysis of results examining the relief of pain and associated disability. While, in principle, yoga may be a useful supportive intervention for many pain-associated conditions, a closer look reveals that current research is largely inadequate and potential harms of yoga need cautious consideration.

Wednesday, January 18, 2012

Unique Uses of Naltrexone in Chronic Pain

Guest Author By guest author, Dmitry M. Arbuck, MD

The use of opioid antagonists in chronic pain management is gaining more recognition and increasing acceptance [7]. Application of these agents, such as naltrexone, is based on the notion that there are fundamental differences between mechanisms of chronic versus acute pain generation and perception. While pain is defined as “an experience” by the International Association for the Study of Pain, this experience can be driven by different underlying physiological and psychological mechanisms, depending on whether the patient is experiencing acute protective pain or a chronic diseased pain state.

Whereas opioid antagonists have no place in the treatment of acute pain, they can be useful for the management of pathologic pain mechanisms evident in chronic pain. Specifically regarding the opioid antagonist naltrexone, there are four general categories of doses that may apply: Pico-Dose, Ultra-Low-Dose, Low-Dose, and High-Dose.

Saturday, January 14, 2012

Chronic Pain Prolongs Postsurgical Pain

Research Update According to recently reported research, patients with chronic pain require special consideration for pain management following any type of surgery. At the least, the postoperative pain is likely to linger longer in these patients, and the pain may be greater if patients were taking opioid analgesics prior to surgery. However, there are still some unanswered questions.

Researchers at the University of Utah School of Medicine, Salt Lake City, followed a convenience sample of 55 patients with preexisting chronic pain for 2 weeks following surgical procedures that were unrelated to their primary chronic pain conditions [Chapman et al. 2011]. Subjects ranged in age from 19 to 85 years (mean 55), 51% were female, and 85% were white. All patients underwent orthopedic surgery, except for one who had a percutaneous nephrolithotomy (kidney stone removal).

Friday, January 13, 2012

Could High-Dose Opioids Conquer Chronic Pain?

Brief Note Contrary to concerns professed lately by opponents of opioid analgesia, higher than usual doses of these medications could be just the thing to prevent acute pain from becoming a chronic, life-changing malady. As was recently successfully demonstrated in a preclinical study, the concept of early, short-term, high-dose opioid administration to quickly manage pain is a radical departure from usual practice and may offer interesting possibilities for better pain care.

Thursday, January 12, 2012

Fibromyalgia Linked to Deficient Vitamin D

Fibromyalgia Fibromyalgia syndrome (FMS) is a chronic pain condition, primarily affecting women, that manifests as widespread musculoskeletal pain, fatigue, sleep disturbance, psychological distress, and cognitive disruptions. A new clinical study suggests that having excessively low levels of vitamin D might play an important role in FMS and ameliorating such deficiencies may be beneficial. However, this was a small, uncontrolled trial and it is important to understand its limitations.

Noha T. Abokrysha, MD, from Cairo University in Egypt, enrolled 30 women with diagnosed FMS in a study to assess the prevalence of vitamin D deficiency and effects of vitamin supplementation. The women — mean age 34.56 ± 8.1 years (range 17 to 51 years) — were all attending a neurology clinic in Saudi Arabia from January to April 2011 [Abokrysha 2012].

Friday, January 6, 2012

Chiropractic or Exercise Tops Meds for Neck Pain

Neck Pain Nonspecific neck pain is a common condition that affects an estimated 70% of persons at some point in their lives, and up to 1 in 5 persons each year. New research suggests that spinal manipulation therapy (chiropractic) or home exercises are equally better than medications for relieving pain. However, there are a number of limitations of this research to consider before leaping to a conclusion that the best medicine for neck pain is no medicine at all.

Researchers at the Northwestern Health Sciences University in Minneapolis, Minnesota, designed a pragmatic, randomized, controlled trial to assess the relative efficacy of spinal manipulation therapy (SMT), medication, and home exercise with advice (HEA) for neck pain in both the short-term (12 weeks) and long-term (52 weeks) [Bronfort et al. 2012]. They enrolled 272 persons aged 18 to 65 years (mean ≈ 48 years) who had nonspecific neck pain for 2 to 12 weeks — most subjects had subacute neck pain lasting more than 4 weeks, beyond the time when acute pain might resolve spontaneously.

Thursday, January 5, 2012

Harms of Epidural Steroid Injections Examined

Injection A surge in epidural steroid injections to alleviate back and neck pain in the United States is bringing with it an increase in severe and unexpected complications, including paralysis and death, according to a report in Bloomberg News [here]. Nearly 9-million Americans received these interventional procedures during 2010 alone, and notices of serious adverse effects have prompted the U.S. Food and Drug Administration, in consultation with an advisory group, to review the safety of steroid injections into the epidural space near the spinal cord.

The FDA review comes during a boom in epidural steroid injections, which take minutes to administer and reap profitable reimbursements from Medicare and private insurers, the Bloomberg report observes. One study, by Laxmaiah Manchikanti, MD, chairman of the American Society of Interventional Pain Physicians (ASIPP), found the number of such injections among Medicare patients increased 159% between 2000 and 2010. Epidural injections are one of many interventional procedures — including implants of spinal cord stimulators — on which Americans spent $23 billion in 2011, up by 231% from 2002, the Bloomberg report notes.

Sunday, January 1, 2012

What’s Really Driving Opioid-Related Death Rates?

Guest Author By guest author, Bob Twillman, PhD, FAPM

On November 1, 2011, the Centers for Disease Control and Prevention (CDC) issued a Morbidity and Mortality Weekly Report (MMWR) titled “Vital Signs: Overdoses of Prescription Opioid Pain Relievers — United States, 1999-2008” [CDC 2011a]. In this document, CDC researchers report finding that opioid analgesics were involved in 14,800 prescription-drug overdose deaths in 2008. They assert that the per capita rate represented by this number is nearly 4 times the rate in 1999; note, however, they do not provide the actual data to support this, although examination of a graph in figure 2 of the MMWR document appears to justify this calculation [also see graph in prior UPDATE here].

CDC also presents data showing that per capita opioid analgesic sales increased in a roughly parallel manner during that interval. The authors of the report carefully avoid saying that the increase in opioid-analgesic-related deaths is caused by increased opioid analgesic sales (perhaps because they do not actually test this relationship statistically), but the clear implication is that increased prescribing is leading to increased sales and deaths. In contrast, an examination of other available data may not be especially supportive of this implication and suggests at least 6 alternative explanations.

Acupuncture a Dud for Pain, But Evidence is Weak

Acupuncture In a multicenter clinical trial, acupuncture proved to be disappointing for the relief of musculoskeletal pain in women taking aromatase inhibitors for breast cancer. Consequently, after an interim analysis, the trial was stopped early. However, this study provides lessons in the complexities of pain research on acupuncture and how weaknesses of evidence preclude valid conclusions.

Research teams in the United States and United Kingdom led by Ting Bao, MD, of the University of Maryland Greenebaum Cancer Center, enrolled 47 postmenopausal women in a double-blind, randomized, sham-controlled trial to assess beneficial effects of acupuncture. All subjects had early-stage breast cancer and experienced painful musculoskeletal symptoms related to aromatase inhibitor therapy for their cancer; none of them had received acupuncture in the prior year. The acupuncture group (N=23) received 8 weekly sessions targeting 15 acupuncture points, while the control group (N=24) received a sham acupuncture procedure at 14 non-acupuncture points. The sham therapy utilized the Park Sham Device, consisting of a nonpenetrating, flat-tipped, retractable acupuncture needle in a telescoping tube [more info here].

Pain Education in Medical Schools Lacking

Pain-Pourri Knowledgeable and compassionate care regarding pain is a core responsibility of health professionals, and this also is associated with better medical outcomes, improved quality of life, and lower healthcare costs. However, according to a new study published in the December edition of the Journal of Pain, even though pain is a most common reason that people seek medical care, education on pain at North American medical schools is relatively minimal, variable, and often fragmentary.

Investigators from the Johns Hopkins University Pain Curriculum Development Team examined curricula at 117 medical schools in the United States and Canada during 2009 and 2010. The authors performed a systematic review analyzing curricular emphasis on topics such as pediatric and geriatric pain, neuropathic pain, cancer pain, pain neurobiology. and pharmacological pain management.

Jan 2012 – Pain Product Announcements & Warnings

Pain Product Announcements Featured Items: extended-release oxymorphone (Opana ER) FDA approved in crush-resistant formulation; first-time generic FDA approval of morphine sulfate ER (Kadian equivalent). — All brand names are trademarks of their respective manufacturers. Compiled by: Winnie Dawson, MA, RN, BSN.

Extended-Release Oxymorphone (Opana ER®) — New Crush-Resistant Formulation FDA Approved
The U.S. Food and Drug Administration granted a December 2011 approval of Endo Pharmaceutical’s crush-resistant formulation of Opana ER. The decision indicates that an FDA evaluation found no significant difference in the efficacy and safety of the crush-resistant product when compared with the original Opana ER tablets approved in June, 2006.