Friday, September 23, 2011

What’s Gone Wrong with Pain Management?

Pain-Pourri A thought-provoking essay by a long-term pain practitioner presents a controversial indictment of current pain management perspectives and approaches. Of special concern are procedural techniques, or interventions, that may be driven more by economics than better patient care and, in the ongoing turf wars between interventionists and medical practitioners, patients with pain are in danger of becoming collateral damage.

Writing online ahead of print publication in the journal Pain Practice, Gerald M. Aronoff, MD, DABPM, suggests pain management today seems all about the money. He wants practitioners to assess whether they are contributing to the problems of excessive and escalating healthcare costs and declining care for patients with pain [Aronoff 2011].

Thursday, September 22, 2011

Electroacupuncture Ineffective for Neuropathy

Acupuncture A recently reported clinical trial examined electroacupuncture — needles inserted at acupoints with electric current applied — for chronic, peripheral neuropathic pain. This therapy afforded no significant pain relief or other benefits; however, the study also serves as an example of poor-quality evidence garnering more attention in a pain journal than it probably deserves.

Writing online ahead of publication in the journal Pain Medicine, researchers in Milan, Italy, report a double-blind, placebo-controlled, cross-over trial to investigate the analgesic efficacy of electroacupuncture (EA) in patients with axonal polyneuropathy [Penza et al. 2011]. They included 16 patients with a diagnosis of chronic neuropathic pain in their lower limbs — Visual Analog Scale [VAS] score > 4.0 for at least 6 months — and taking analgesic medications for at least 3 months at stable doses. There were 9 females and 7 males enrolled; mean age 64.9 years (range 43-75 years).

Friday, September 16, 2011

Myth-Representations of Opioids & Their Risks

Editor's Notebook After more than a decade of increasing opioid prescribing for chronic pain, the pendulum may be swinging the other way. A recent editorial in a major journal appears to reflect common misunderstandings and negative perspectives on the effectiveness and potential harms of opioids. So, it seems essential at this time to dispel the myths and shift the dialog back toward patient needs and benefits of opioids.

Writing in the September 17, 2011 edition of the Archives of Internal Medicine, Deborah Grady, MD, MPH, and colleagues from the University of California at San Francisco and Los Angeles, discuss “Opioids for Chronic Pain” [Grady et al. 2011]. However, a more apt title might have been, “Why Not to Use Opioids for Chronic Pain,” as they present negatively biased views about risks and harms of these medications. While we do not question that this editorial was well-intended, in the interest of fair balance there are numerous misrepresentations — expressing a false mythology surrounding opioid analgesics — that must be challenged.

Chondroitin for Hand Osteoarthritis? Maybe Not.

Hand OA A clinical trial of chondroitin sulfate for osteoarthritis of the hand reported modest improvements in pain and functionality, compared with placebo. However, realizing full benefits of active therapy required 6 months and there were no clinically important gains in morning stiffness or grip strength. While certain questions remain unanswered, it seems doubtful that chondroitin is a viable alternative therapy for most patients with arthritic hand pain.

A team of rheumatologists in Switzerland conducted a single-center, randomized, placebo-controlled, double-blind, clinical trial of highly purified chondroitin sulfate in patients with hand osteoarthritis (OA) [Gabay et al. 2011]. Writing in an advance online edition of the journal Arthritis & Rheumatism, they report enrolling 162 patients with confirmed hand OA, including joint pain of at least 40 mm on a 0-to-100 mm visual analog scale (VAS, 100 mg being worst possible pain) and impairment level of at least 6 on a 0-to-30 Functional Index for Hand OA (FIHOA, 30 being worst possible score).

Sunday, September 11, 2011

What Works Best for Acute Pain? Evidence Review.

Acute Pain A Cochrane Review of data from about 45,000 patients involved in approximately 350 individual clinical trials provides evidence of what to expect from commonly used pain relievers taken at specific doses for acute postoperative pain. The review also identifies analgesics for which there is only poor or no reliable evidence. Topping the list for pain relief were etoricoxib and oxycodone-plus-acetaminophen, while codeine scored the worst.

Working at the Oxford Pain Research Unit at Oxford University in the UK, R. Andrew Moore, MD, and colleagues analyzed the findings of 35 Cochrane Reviews of randomized clinical trials testing how well different analgesics work when used for moderate to severe postoperative pain [Moore et al. 2011]. Their review-of-reviews, or overview, is reported in the latest edition of The Cochrane Collaboration Library, which provides some of the most extensive and quantitatively rigorous investigations of clinical evidence.

Saturday, September 10, 2011

Vitamin D Relieves Pain in Breast Cancer, Study

Vitamin D A new study demonstrates that high-dose vitamin D helps to relieve debilitating joint and muscle pain in women with breast cancer who are taking estrogen-lowering drugs to shrink the tumors. This is yet another demonstration of vitamin D’s possible role in maintaining bone health while also aiding musculoskeletal aches and pains.

According to a news release from Washington University, St. Louis [here], drugs known as aromatase inhibitors are commonly prescribed to shrink breast tumors fueled by the hormone estrogen and help in preventing cancer recurrence. They are less toxic than chemotherapy but, for many patients, the drugs may cause severe musculoskeletal discomfort, including pain and stiffness in the hands, wrists, knees, hips, lower back, shoulders, and feet. It is unknown exactly why these discomforts occur but as many as half of treated women can experience the symptoms and the pain can be so debilitating that patients stop taking aromatase inhibitors. Vitamin D appears to offer some help in ameliorating the discomfort.

Tuesday, September 6, 2011

Is Aspirin a First-Line Therapy for Headache?

Headache Recently reported research proposes that simple aspirin should be favored over triptan-class drugs as first-line therapy for both migraine and tension-type headaches, regardless of pretreatment pain intensity. While this may make sense for certain patients, there are some concerns with this particular research that merit closer inspection.

Stepped care in migraine management generally relies on treatments targeting symptoms as first-line therapy, reserving triptan-class agents for patients in whom this proves ineffective. Alternatively, stratified care of migraine chooses equally between symptomatic therapy (eg, with aspirin) and triptans on an individualized basis, according to perceived illness severity. A team of European researchers [Lampl et al. 2011] examined whether pain severity — moderate or severe — would (or should) make a difference in recommending aspirin as a first-line therapy for symptomatic relief of migraine or acute episodic tension-type headache (ETTH).

Friday, September 2, 2011

PENS for Superficial Neuropathic Pain Tested

Neuropathic Pain A well-designed but small study of PENS (percutaneous electrical nerve stimulation) for superficial, chronic nerve-related pain found that the modality was effective in providing short-term relief. However, while this approach may be promising for certain manifestations of neuropathic pain, the many limitations of this trial and needs for further research should be taken into account.

PENS is an interventional electrical neuromodulation technique that has demonstrated some therapeutic potential in various chronic pain conditions during recent years, but well-blinded controlled studies of this modality have been lacking, according to a research team from the UK. Therefore, Jon H. Raphael, MD, and colleagues conducted a randomized, double-blind, sham-controlled, crossover trial in 31 patients experiencing chronic pain with surface hyperalgesia to investigate the efficacy of PENS [Raphael et al. 2011].

Thursday, September 1, 2011

Rules Hurt Patients with Pain in Washington State

Legal Side of Pain Practice Imagine having such tight regulations on prescribing a class of medications, such as anti-hypertensives, that practitioners stop using them altogether for patients with high blood pressure. In effect, something similar may be happening with opioid analgesics in Washington state where aggressive new pain-management laws, meant to curb opioid overdose deaths, have some prescribers shunning these medications and leaving patients without adequate pain relief. Could this portend what might lie ahead elsewhere?

Writing in the Seattle Times [August 27, 2011], reporter Carol M. Ostrom examines early reactions to new regulations going into effect January 1, 2012 in Washington state that will restrain the prescribing of opioid analgesics. Overall, these rules, previously discussed in an UPDATE [here], require detailed evaluations and documentation for each patient with chronic pain; including a treatment plan, consent agreement, and drug testing. Prescribers also are mandated to complete special education on opioid prescribing, and to consult with a pain management specialist if a patient needs more than 120 mg/day of morphine or its equivalent, or if the patient has suspected risks of substance misuse or psychiatric complications.

Sep 2011 – Pain Product Announcements & Warnings

Announcements & Warnings Featured Items: tapentadol extended-release tablets (Nucynta) approved for chronic pain; subcutaneous abatacept (Orencia) approved for rheumatoid arthritis; citalopram hydrobromide (Celexa) safety warning. — All brand names are trademarks of their respective manufacturers. Compiled by Winnie Dawson, MA, RN, BSN.

Tapentadol-ER (Nucynta®) for Chronic Pain — FDA Approved
Janssen Pharmaceuticals announced an August 2011 U.S. Food and Drug Administration (FDA) approval for their extended-release formulation of tapentadol, Nucynta ER. This centrally-acting synthetic analgesic is a Schedule II controlled drug designed to be taken twice daily for the management of moderate to severe chronic pain in adult patients who need continuous, around-the-clock pain relief for an extended period of time.