Friday, May 25, 2012

Docs Who Shun Drug Reps Are Misguided

Prescribing After years of reducing their contact with pharmaceutical sales representatives, healthcare providers and their patients now face unintended consequences. According to a new study, practitioners who rarely meet with pharma reps — or who do not meet with them at all — are much slower to stop prescribing medicines with “black box” warnings and to adopt first-in-class therapies that may benefit patients. Concerns about undue pharmaceutical industry influence may be driving clinical practice in the wrong direction.

According to the study, published May 21, 2012, in The Journal of Clinical Hypertension, clinicians whose access to pharmaceutical sales representatives is limited can take more than 4 times longer to change prescribing practices based on new information than their peers who have more frequent contact [Chressanthis et al. 2012]. And, this longer response time holds true whether the physicians are responding to “positive news” related to an innovative therapy or “negative news” related to a newly discovered medicine risk.

Thursday, May 24, 2012

Ergonomics at the Computer Stems Pains & Strains

Ergonomics Working at a computer for long hours, whether a desktop or laptop, can bring about serious back or neck pain, eye strain, headaches, and even carpal tunnel syndrome. Better attention to ergonomics can often help to prevent or relieve these ailments, and a series of short video presentations tells how. This is important for both healthcare providers and their patients.

Ergonomics is an approach to adapting the work setting and equipment to the user, rather than the person having to adjust in uncomfortable ways to poor conditions. A brief, entertaining, 3-minute YouTube video [here] offers good advice for men, women, and children who use laptop computers. At this link there also will be other instructive short videos on ergonomics at the computer at home, at the office, or while on the road that are worth watching. For example, see the video on safe laptop use while traveling and in hotels [here].

Wednesday, May 23, 2012

Managing Risk Factors to Prevent Migraines

Conference Notes The latest genetic and biological research shows that migraine is most likely a neurological, not a vascular, disorder and newer treatments in development target peripheral and central nervous systems, according to David Dodick, MD, speaking at American Pain Society's 31st Annual Scientific Meeting in mid-May 2012. Migraine is generally an inherited disorder characterized by physiological changes in the brain involving central neuronal modulation, as well as structural brain changes if attacks occur frequently; so, it is essential that practitioners help patients to utilize preventive strategies.

Friday, May 18, 2012

Early Care for Low-Back Pain is Essential

Low-Back Pain Although nonspecific low-back pain is a highly prevalent condition, its clinical course over time remains uncertain. A large-scale meta-analysis of available research suggests that seeking treatment sooner rather than later can be important for pain relief and reduced disability; however, residual effects still may linger for a year or longer.

A research team at the University of Sydney, Australia, systematically reviewed studies investigating the clinical time course, or prognosis, of pain and disability in patients with either nonspecific acute or persistent low-back pain [Costa et al. 2012]. In a meta-analysis, they included only prospective studies that measured back pain, disability, or a global measure of recovery.

Thursday, May 17, 2012

Do Short-Acting Opioids Affect Sex Hormones Less?

Sex HormonesSex hormone deficiencies, or hypogonadism, can be a common adverse effect of ongoing opioid use in both men and women. A newly reported study found that this problem was less prevalent in a sample of men taking short-acting rather than long-acting opioid analgesics for chronic pain. However, this was a preliminary investigation and study limitations should be taken into account. Furthermore, hypogonadism is an effect that can be medically managed and need not automatically require discontinuation of opioids or a change of formulation.

In a poster presentation at this year’s meeting of the American Academy of Pain Medicine (AAPM), a team of investigators from the Kaiser Permanente Health Care System in Northern California reported on a comparison of hypogonadism in men taking daily long-acting (N=46) versus short-acting (N=35) opioid analgesics for chronic noncancer pain [Rubinstein et al. 2012]. They examined total testosterone levels in the 81 men, aged 18 to 80 years, during 2009-2010. All of them had been on stable daily opioid dosing for at least 3 months and none had a prior diagnosis of hypogonadism.

Wednesday, May 16, 2012

Neuropathy Inadequately Diagnosed & Treated

Neuropathy A recent national poll found that persons with neuropathy face delayed diagnoses, inadequate pain care, and distressing life changes due to their painful disorders. Peripheral neuropathy affects nearly 7% of Americans and from 2% to 8% of populations worldwide. The many types of neuropathy pose diverse challenges for patients, their families, and healthcare providers, yet relatively few resources are devoted to research and treatment of these disorders.

More than 1,900 patients responded to an online survey recently conducted by The Neuropathy Association [full results here]. A majority of survey participants indicated they experienced an extended period of time from symptom onset to diagnosis of their neurological disease — taking more than one year in 75% of cases, and more than 5 years for 20% of patients.

Friday, May 11, 2012

Is Misuse of Meds by Pain Patients Rampant?

Medication Misuse A nationwide study found that 3 in 5 patients may be noncompliant with prescribed drug regimens, as detected by urine drug testing. The findings further suggest a majority of persons treated for pain may be misusing medications in ways that pose health risks; from missing doses to taking unauthorized drugs. However, there are many factors that might account for these outcomes and should be considered before leaping to conclusions about patient misbehavior.

The recently released study — a Quest Diagnostics Health Trends™ Report titled, “Prescription Drug Misuse in America, Laboratory Insights into the New Drug Epidemic” — describes an analysis of roughly 76,000 urine drug tests (UDT) of patients from 10 years of age and older, in 45 states and the District of Columbia, performed during 2011. Samples came from a wide variety of practices, including pain specialty clinics and hospitals, but excluded drug rehabilitation clinics. [The full report PDF is available here.]

Wednesday, May 9, 2012

Sad News: American Pain Foundation Closes Down

In The News Persons with pain across America, and worldwide, lost a leading ally in the War on Pain. After 15 years, and without warning, the American Pain Foundation closed-down operations. And so, the lights went out on the largest national advocacy organization serving people living with pain, their caregivers and healthcare providers, and allied organizations. Who will fill the void?

A brief notice appearing May 8, 2012, at the American Pain Foundation (APF) website simply stated, “With deep regret and heavy hearts, we sadly inform you that due to irreparable economic circumstances, APF must cease to exist, effective immediately.” It went on to say, “The Board and staff have worked tirelessly over many months to address a significant gap between available financial resources and funds needed to remain operational. Unfortunately, the economic situation has not changed in any meaningful way, despite our best efforts.”

Thursday, May 3, 2012

New Survey: Half of U.S. Adults Have Chronic Pain

Chronic Pain According to a just-released large survey from the Gallup organization, nearly half (47%) of American adults reported having some type of chronic pain in 2011, which would amount to at least 111 million persons. This incredible prevalence of pain appears to confirm earlier estimates by the U.S. Institute of Medicine; although, despite the dissent of some doubters, the numbers actually may be underestimates.

During 2011, an ongoing Gallup-Healthways survey randomly contacted more than 353,000 U.S. adults, aged 18 and older, via telephone. The survey included persons living in all 50 states and the District of Columbia, and calls were made to both landline telephones and cellular phones. Respondents were asked if they had a neck or back condition, a knee or leg condition, or another condition that caused recurring pain in the last 12 months [full report here].

Wednesday, May 2, 2012

Fallacies of Evidence in Pain Research

Making Sense of Pain Research Part 12 – How Critical Thinking Goes Awry

The greatest mistake that consumers of pain research can make is to blindly accept that published results and conclusions, or narrative arguments of some sort, are undoubtedly reasonable and true. We can either become wise or be fooled by commonplace fallacies in the pain literature, which subvert critical thinking to create flawed perceptions of reality. Although uncertainty and doubt are inherent in all scientific endeavors, a most important lesson is depicted in the Latin phrase, Ubi Dubium, Ibi Intellectum — where there is doubt, there also can be understanding.

Tuesday, May 1, 2012

May 2012 – Pain Product Announcements & Warnings

Pain Product Warnings Featured Items: rotigotine transdermal system (Neupro) approved for RLS; adalimumab (Humira) European approval for colitis; fentanyl patch safety alert; proton pump inhibitor (PPI) alert for C. difficile-associated diarrhea; Savella and Neurontin added to FDA Watch list; morphine sulfate injectable recall. — All brand names are trademarks of their respective manufacturers. Compiled by Winnie Dawson, MA, RN, BSN.

Rotigotine Transdermal System (Neupro®) – approved for RLS
U.S. Food and Drug Administration (FDA) officials gave UCB, Inc. an approval in April 2012 to market Neupro for the treatment of core symptoms in moderate-to-severe primary restless legs syndrome (RLS). This continuous delivery skin patch contains the dopamine agonist rotigotine which is believed to work by stimulating dopamine receptors in areas of the brain that regulate movement. This approval also included the indication of advanced stage idiopathic Parkinson's Disease, and the drug was previously approved for the signs and symptoms of early-stage idiopathic Parkinson's Disease. Approvals were based on results of 5 randomized, double-blind placebo-controlled trials, with 2 fixed-dose trials providing efficacy data for the treatment of RLS. The most common adverse effects reported included nausea, application site reactions, somnolence, dizziness, and headache. The patch should not be used by pregnant women or patients who have allergic-type reactions to sulfites. See the Neupro Prescribing Information for full administration and safety instructions.