Thursday, June 28, 2012

The “Integrative Pain Management” Controversy

Integrative Pain ManagementIntegrative pain management — combining the wisdom of nature with the rigors of modern science — is a growing movement in the pain field today. Yet, it is controversial, with some claiming that “integrative” is just the latest buzzword for a collection of superstitions, myths, or pseudoscience that have gone by various names through the years. The epicenter of the integrative medicine debate, in the United States at least, is at the National Center for Complementary and Alternative Medicine (NCCAM).

NCCAM is one of 27 institutes and centers that make up the U.S. National Institutes of Health (NIH) and is the government’s lead agency for scientific research on complementary and alternative medicine (CAM). The Center sponsors and conducts research using scientific methods to study CAM, which is defined simply by NCCAM as a group of diverse medical and health care interventions, practices, products, or disciplines that are not generally considered as part of conventional medicine.

In a recent posting at the NCCAM Research Blog [here], agency Director, Josephine P. Briggs, MD, explores what “integrative” means and concedes that the term has various connotations. She observes that the legislation authorizing the Center in the late 1990s clearly emphasized integration, as follows:

Wednesday, June 27, 2012

“Narcotics” vs “Opioids” – Language Matters

Language MattersJargon often influences attitudes and impedes communication between healthcare providers and patients, which can impact the quality of pain care. Nowhere is this more apparent than in the use of “narcotics” rather than “opioids” in reference to pain relievers, and the results of a recently reported study comparing patients’ understandings of the two terms were both surprising and disturbing.

In the study — conducted by Lorraine Wallace, PhD, of Ohio State University, and colleagues — a convenience sample of 188 English-speaking women who were visiting a primary care clinic completed a 4-question survey. The women were generally healthy, aged 21 to 45 years, and 81% were Caucasian. Each participant was randomly assigned to either a survey version using the term “opioid” or a second version using “narcotic” as follows [Wallace et al. 2012]:

  1. What is [an/a opioid/narcotic]?

  2. Give an example of [an/a opioid/narcotic]?

  3. Why does someone take [an/a opioid/narcotic]?

  4. What happens when someone takes [an/a opioid/narcotic] for a long time?

Thursday, June 21, 2012

NSAIDs May Hinder Not Help Sore Muscles

NSAIDsMany persons experience muscle pain after heavy exercise, which may persist for some time. Taking nonsteroidal anti-inflammatory drugs (NSAIDs) to ease the discomfort is common practice; however, new research suggests that this may not be beneficial. In fact, the pain may be prolonged with NSAIDs.

At the latest annual meeting of the European League Against Rheumatism (EULAR 2012), Matthias Rother, MD, PhD — of International Medical Research in Graefelfing, Germany — and colleagues presented research examining the effects of two NSAIDs with different anti-inflammatory potency on muscle soreness due to strenuous exercise. They conducted two randomized, placebo-controlled studies of similar design in which muscle soreness was induced by having healthy subjects walk down stairs, the exact number of which was determined by body weight, but similar to walking down from the top of a 100-story building.

Wednesday, June 20, 2012

How the War on Rx-Drugs Victimizes Pain Patients

In the NewsIn a battle against prescription drug abuse and diversion, primarily involving opioid pain relievers, the U.S. Drug Enforcement Agency (DEA) has launched attacks on wholesalers and pharmacies within the legitimate supply chain. Questions are being raised about the foresight of such tactics, as healthcare providers are becoming leery of prescribing and severe shortages of these vital analgesics loom over the horizon. In the end, patients with pain may become collateral damage in this “War on Rx-Drugs.”

According to a recent report from Reuters news service [“U.S. War on Drugs Moves to Pharmacy from Jungle”; June 16, 2012, here], in response to ever-increasing concerns about the diversion of prescription pain relievers to illegitimate use, the DEA has beefed up its efforts at deterrence and is deploying many of the tactics it uses to combat illegal drugs, such as wire taps, undercover operations, and informants.

Such efforts have helped it dismantle many “pill mills” — bogus pain clinics writing thousands of questionable prescriptions — as well as rogue Internet pharmacies. However, the agency is now applying the same tactics to prosecute the legitimate pharmaceutical supply chain, including wholesalers and pharmacies that must follow strict record-keeping and security rules to prevent drug diversion.

Friday, June 15, 2012

Depression & Anxiety Hinder Pain Relief

Pain-DepressionIt makes sense that anxiety, depression, and chronic pain often occur together and might influence each other in negative ways. Consequently, a newly-reported trial suggests that the assessment of patient mood, and appropriate treatment for anxiety and/or depression, can be important for maximizing the effectiveness of pain management therapies, such as with opioid analgesics. However, as is often the case, there were limitations of this research that should be taken into account in rating the quality of the evidence.

Patients with chronic noncancer pain frequently report symptoms of depression and anxiety (negative affect), which are associated with higher ratings of pain intensity and a greater likelihood of being prescribed long-term opioid therapy. Writing in an advance online edition of the journal Pain Practice, researchers report a study in patients with low back pain that tested the hypothesis that initial levels of negative affect can predict opioid-treatment-related success in terms of pain intensity, disability, and other variables.

Thursday, June 14, 2012

UDT Cannot Assess Rx-Dose Compliance, Court Rules

UDTUrine drug testing, or UDT, can be an important component of effective clinical pain management. However, a recent court decision has labeled claims by a major diagnostic testing laboratory — that their approach to UDT could help clinicians identify potential abuse, misuse, or diversion of patient medication — as false and deceptive advertising. This latest judgment reinforces the principle that UDT must be carefully and properly used as a tool for helping to gauge patient compliance with medication regimens.

Ameritox Ltd, a diagnostic testing laboratory headquartered in Baltimore, Maryland, has long claimed that its proprietary Rx Guardian℠ and Rx Guardian CD℠ monitoring systems based on UDT results allow practitioners to determine how patients have been taking their pain medications, both in terms of the dosage and frequency of drug use. Now, a unanimous Federal jury verdict and a confirming order by United States District Court Judge Benson Everett Legg has determined that Ameritox's advertising claims about its Guardian systems are literally false and potentially deceptive.

Tuesday, June 12, 2012

INvisible Project Makes Chronic Pain Tangible

Guest AuthorBy guest author, Nicole Hemmenway

Although chronic pain affects more than 100 million Americans, according to the U.S. Institute of Medicine, most people still do not understand the challenges that those with pain endure. Pain affects every aspect of a person’s life. It can destroy families and friendships, careers and livelihoods and the joys of life. It can even make a person feel insignificant and alone.

The U.S. Pain Foundation [U.S. Pain, website here] was founded in 2006 as a nonprofit organization dedicated to serving those with pain and their care providers. Created for people with pain by people with pain, our mission is to inform, empower, and advocate on behalf of the pain community. As an organization, we recognize that we may not all have the same diagnosis or disability. With that said, U.S. Pain believes that the physical agony and emotional heartache each of us faces is universal. Each of us deals with the same struggles and frustrations, just as each of us possesses the same internal strength and desire to find answers.

Friday, June 8, 2012

Crackdown on Rx-Opioids Fuels Heroin Abuse

In The NewsAccording to recent news reports from MSNBC [here] and Join Together [here], the crackdown on prescription opioid analgesics in the United States is fueling a resurgence of heroin abuse and addiction. And, experts note, heroin today is inexpensive, powerful, and more destructive to individuals and society than Rx-opioids.

Law enforcement officials report that there is a flood of cheap heroin coming from Mexico — now a leading source of the drug in the U.S. — and it is appearing in new areas than before, including upscale suburbs, where the drug was once hard to find. With an increased availability of heroin has come a spike in the number of visits to emergency departments for issues related to substance abuse, according to the national DrugAbuse Warning Network [here].

Until recently, heroin addiction was seen mostly in men living in urban areas, many of them minorities, the news reports observe. Today, in states like Ohio, most people entering treatment programs for heroin addiction are white, and many are young. They come from both poor areas and wealthy suburbs, and many are female.

Thursday, June 7, 2012

Is Spinal Manipulation Ineffective for Pain?

CAMRecent systematic reviews assessed the effectiveness of spinal manipulation therapy, such as chiropractic, for managing various types of pain. Overall, this modality was found to be ineffective for relieving most types of pain and of debatable clinical usefulness for others, such as back pain. However, there also have been many weaknesses in past research that need further attention.

Among the many treatments often suggested for pain is spinal manipulation, as commonly used by chiropractors, and also by osteopaths, physiotherapists, or other manual therapists. Writing in an early online edition of the journal Pain Medicine, Paul Posadzki, PhD — from the Department of Complementary Medicine, Peninsula Medical School, Exeter, UK — defines spinal manipulation as “the application of high-velocity, low-amplitude manual thrusts to the spinal joints slightly beyond the passive range of joint motion” [Posadzki 2012].

The technique aims to correct misalignments or so called “subluxations” of the joints (both spinal and peripheral). However, as Posadzki notes, it has been suggested that such subluxations lack biological plausibility, and the safety and cost-effectiveness of spinal manipulation have also been questioned. Yet, spinal manipulation is widely used for a range of pain-related and other conditions.

Friday, June 1, 2012

Acetaminophen Overuse is Common & Risky

Acetaminophen Practitioners and their patients are increasingly turning to acetaminophen for the management of mild to moderate pain. However, new research affirms that confusion and ignorance about the proper use of over-the-counter medications containing acetaminophen is commonplace, and the unintentional overuse and overdose of acetaminophen has the potential to become a health threat of major proportions.

A new study by Michael Wolf, MD, from Northwestern University in Chicago, and colleagues cautions that significant numbers of adults are at risk of unintentionally overdosing on over-the-counter (OTC) acetaminophen (or APAP, also called paracetamol outside the U.S.). Writing in an early online edition of the Journal of General Internal Medicine, the researchers report on assessments of 500 adult patients (ages 18 to 80) receiving care at outpatient general medicine clinics in Atlanta and Chicago between September 2009 and March 2011 [Wolf et al. 2012]. More than half of the patients reported some APAP use and nearly 1 in 5 (19%) were “heavy users”; that is, they had taken the analgesic every day, or at least a couple of times a week, during the previous 6 months.

Vitamin D Prevents Falls, Disability in Elderly

Vitamin D Newly reported research studies reiterate the benefits of vitamin D in older adults for helping to prevent falls, maintain mobility, and reduce age-related disability. However, optimal dosing strategies and blood levels of vitamin D in this population need further elaboration, and the quantity and quality of clinical research in this area has been disappointing.

Preventing Painful Falls in Older Adults

The United States Preventative Services Task Force (USPSTF) recently released updated clinical guidelines on the prevention of painful falls in community-dwelling older adults [access document here]. Two primary recommendations for fall prevention were vitamin D supplementation and exercise, as also reported in an early online edition of the Annals of Internal Medicine by Virginia Moyer, MD, MPH, on behalf of the USPSF [Moyer 2012, see ref below].