Comments on Pain-Topics.org News/Research UPDATES: Dosing Ratios: Morphine-to-Methadone Rotation

If I read the information correclty, then we would...

2009-07-30T11:43:48.590-05:00

If I read the information correclty, then we would want to be more conservative when switching form Methadone to morphine so the conversion ration would not be 1:8 to 1:11 but would be even lower than the 1:4.7 conversion listed by Walker PW et al, 2008. Therefore, would it be recommended to possibly use a conversion ration of 1:1 to 1:3 when converting from methadone to morphine as to not over

If possible, I would like to hear some response on...

2009-07-30T09:13:44.715-05:00

If possible, I would like to hear some response on the conclusion above "Therefore, it would seem prudent to use a ratio for oral methadone to oral morphine of between approximately 1:8 to 1:11 as reported is some case reports by Lawlor et al, 1997 and Ripamonti et al, 1998. These reports were in patients with cancer. However, if treating chronic non-cancer pain it seems that this may also

In reference to the article “Conversion Ratios for...

2009-07-29T14:29:36.570-05:00

In reference to the article “Conversion Ratios for Rotation from Methadone to Other Opioids” in your “e-Briefing Newsletter” (2006, Vol 1, No 2, page 10). Go to: http://pain-topics.org/pdf/e-Briefing_Vol1_No2_2006.pdf and the primary article by Walker PW et al, 2008 Switching from methadone to a different opioid: what is the equianalgesic dose ratio? The ratio of oral methadone to oral morphine

In response to the question above -- according to ...

2009-07-28T11:49:12.030-05:00

In response to the question above -- according to the literature, numerous factors may influence the safety and tolerability of rotations from methadone to other opioids, including: patient age or gender, expected pain control, existing disease, concomitant medications, and genetic influences. For some preliminary recommendations on equianalgesic dosing, see the article, “Conversion

What type of a conversion ratio or morphine equiva...

2009-07-28T11:05:40.685-05:00

What type of a conversion ratio or morphine equivalent dose are you using when switching from methadone to morphine in a patient who has been receiving methadone for chronic pain.